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KMID : 1161520150190060365
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Animal Cells and Systems
2015 Volume.19 No. 6 p.365 ~ p.373
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Effect of histamine receptors agonists or antagonists administered intracerebroventricularly and intrathecally on the blood glucose level in immobilization stress model
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Sharma Naveen
Sim Yun-Beom
Park Soo-Hyun
Kim Sung-Su
Lee Jae-Ryeong
Jung Jun-Sub
Suh Hong-Won
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Abstract
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Effects of histamine receptors agonists or antagonists administered centrally (supraspinally or spinally) on immobilization stress-induced blood glucose levels were studied in Institute for Cancer Research mice. Mice were pretreated intracerebroventricularly (i.c.v.) or intrathecally (i.t.) with histamine (H1, H2, H3 and H4) receptor agonists or antagonists 10?min prior to immobilization stress (IMO) stimulation for 30?min. We found that the increased blood glucose level induced by IMO was attenuated by the i.c.v. pretreatment with α-methylhistamine (H3 agonist). However, H3 antagonist, H1, H2 and H4 receptor agonists and antagonists did not affect the blood glucose level. Also, i.t. pretreatment with α-methylhistamine or VUF 8430 attenuated the increased blood glucose level induced by IMO. In addition, cetirizine and carcinine enhanced the increased blood glucose level induced by IMO. However, the blood glucose level was not affected by H1 and H2 receptor agonists, H2 and H4 receptor antagonists. Corticosterone and insulin levels were also measured in α-methylhistamine (i.c.v or i.t) and with VUF 8430, carcinine and cetirizine (i.t.) treated group. We found that the corticosterone level was increased only by i.t treatment with α-methylhistamine, whereas the insulin level was attenuated by i.c.v or i.t. treatment with α-methylhistamine and i.t treatment with VUF 8430, carcinine and cetirizine. Our results suggest the active involvement of histamine receptor in blood glucose regulation in IMO.
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KEYWORD
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immobilization stress, histamine, spinal cord, blood glucose
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